I. Reactive Intermediates in Toxicology and Carcinogenesis: Role of Covalent Binding. - 1. Introduction to the Concept of Reactive Intermediates. - 2. The Concept of Reactive Electrophilic Metabolites in Chemical Carcinogenesis: Recent Results with Aromatic Amines Safrole and Aflatoxin B1. - 3. Kinetics of Reactive Metabolites and Covalent Binding in Vivo and in Vitro. - 4. Biochemical Aspects of Toxic Metabolites: Formation Detoxication and Covalent Binding. - 5. Discussion. - II. Formation of Reactive Intermediates. - 6. Mechanism of Microsomal Monooxygenases and Drug Toxicity. - 7. Discussion. - 8. Aryl Hydrocarbon Hydroxylase: Induction. - 9. Discussion. - 10. Benzo [a] pyrene Metabolism: Enzymatic and Liquid Chromatographic Analysis and Application to Human Liver Lymphocytes and Monocytes. - 11. Discussion. - 12. Genetic Differences in Benzo [a] pyrene Carcinogenic Index in Vivo and in Mouse Cytochrome P1 450-Mediated Benzo [a] pyrene Metabolite Binding to DNA in Vitro. - 13. Discussion. - 14. Formation of Toxic Intermediates in Fetal Tissues. - 15. Discussion. - 16. The Possible Role of Trout Liver Aryl Hydrocarbon Hydroxylase in Activating Aromatic Polycyclic Carcinogens. - 17. Metabolic Activation of Methyldopa by Cytochrome P450-Generated Superoxide Anion. - 18. Formation of Tertiary Amine N-Oxide and Its Reduction by Rat Liver Microsomes. - III. Inactivation of Reactive Intermediates. - 19. Epoxide Hydratase: Purification to Apparent Homogeneity as a Specific Probe for the Relative Importance of Epoxides among Other Reactive Metabolites. - 20. Glutathione S-Transferases. - 21. Discussion. - 22. UDPGlucuronosyltransferase: Substrate Specificity and Reactivation after Partial Separation from Other Membrane Components. - 23. Discussion. - 24. Inactivation of Reactive Intermediates in Human Liver. - 25. Discussion. - 26. Nucleotide Pyrophosphatase as a Competitor of Drug Hydroxylation and Conjugation in Rat Liver Microsomes. - IV. Specific Reactive Intermediates. - 27. Metabolic Activation of Hydrazines to Highly Reactive Hepatotoxic Intermediates. - 28. Discussion. - 29. Activation of Nitrite. - 30. Discussion. - 31. Benzene Metabolism and Toxicity. - 32. Benzene and p-Xylene: A Comparison of Inhalation Toxicities and in Vitro Hydroxylations. - 33. Discussion. - 34. Hepatotoxicity of Carbon Disulfide and of Other Sulfur-Containing Chemicals: Possible Significance of Their Metabolism by Oxidative Desulfuration. - 35. Studies of the Formation of Reactive Intermediates of Parathion. - 36. Discussion. - 37. Metabolism and Biological Activity of Benzo [a] pyrene and Its Metabolic Products. - 38. Discussion. - 39. Polycyclic Hydrocarbon Epoxides as Active Metabolic Intermediates. - 40. Stereoselective Synthesis and Reactions of a Diol-Epoxide Derived from Benzo [a] pyrene. - 41. Discussion. - 42. Additional Routes in the Metabolism of Phenacetin. - 43. Biliary Metabolites of Paracetamol in Relation to Dose Level and Various Pretreatments. - 44. Studies on Pharmacokinetics of N-Demethyldiazepam the Active Main Metabolite of Diazepam. - V. Reactive Intermediates in Lipid Peroxidation. - 45. Regulation and Effects of Lipid Peroxidation in Isolated Hepatocytes. - 46. Discussion. - 47. New Data Supporting an Obligatory Role for Lipid Peroxidation in Carbon Tetrachloride-Induced Loss of Aminopyrine Demethylase Cytochrome P450 and Glucose-6-phosphatase. - 48. Discussion. - 49. Binding of Haloalkanes to Liver Microsomes. - 50. Discussion. - 51. Degradation of Cytochrome P450 Heme and Lipid Peroxidation in Lead-Poisoned Rats. - VI. Reactive Intermediates in Carcinogenesis. - 52. The Effects of Microsomal Enzymes on Chemical Oncogenesis in Culture. - 53. Discussion. - 54. Role of Covalent Binding in Carcinogenicity. - 55. Discussion. - 56. Interactions of Carcinogens with Human Cell DNA: Damage and Repair. - 57. Discussion. - 58. The Origin Present Status and Trends of Toxicology: A Review of the Symposium in Turku 1975. - Participants. Language: English